This document provides comprehensive guidance on designing solutions for running virtual machines using OpenShift Virtualization on premises. It is particularly useful for users migrating from VMware to OpenShift Virtualization. The document addresses key challenges such as infrastructure architecture, application availability, data resiliency, scaling out, and platform maintenance. It also explains how IBM Fusion HCI can be leveraged to meet these needs, offering detailed blueprints for various deployment scenarios, including new infrastructure and reusing existing infrastructure. Additionally, it covers disaster recovery strategies and provides insights into the use of IBM Storage FlashSystem for low latency storage. This document is essential for anyone looking to implement or manage OpenShift Virtualization environments effectively.