Using Microsoft ODX on Microsoft Hyper-V hosts
Ensure that you are familiar with the Microsoft Hyper-V host attachment requirements to verify and troubleshoot your configuration.
ODX is disabled by default so that you can enable the MPIO feature. After enabling the MPIO feature, you can enable the ODX by entering the chsystem -odx on CLI command.
Although Microsoft ODX is supported, the volumes that are mapped to the host are not ODX capable in Windows until they are unmapped and then mapped again.
You can add new LUNs to a Windows host for consumption of an ODX-aware application. The system array works best with ODX when LUNs that are exported to the Windows host are formatted with 32 KB NTFS cluster size. Therefore, ensure that the allocation unit size for the New Technology File System (NTFS) is greater than or equal to 32 KB. The default on the Windows Server 2012 release 2 is 4 KB, which might not result in the performance that the system can deliver.