Defining the number of disk devices on a VMware ESXi/ESX host
The maximum number of disk devices that are supported on a VMware ESXi/ESX server is 512 LUNs per host. The embedded multipathing capability of the VMkernel can manage up to 2048 paths.
The maximum number of LUNs that can be used must accommodate these two limitations.
VMware configuration maximums can be viewed at: https://configmax.vmware.com/.