Opt-out handling
In Acoustic Campaign, your organization can maintain opt-outs on a database level or an organization level.
Maintaining opt-outs on a database level
If you choose to maintain opt-outs on a database level, a contact who opts out of an email sent to a specific database is marked as opted out on that database only, and is suppressed (not sent to) on subsequent emails to the same database. The suppression happens at send time when Acoustic Campaign is determining which contacts should receive a given mailing. They continue to receive mailings sent to all other databases.
Maintaining opt-outs on an organization level
If you chose to maintain opt-outs on an organization level, a contact who opts out of an email sent to any database is added to an organization-level suppression database (typically referred to as the master suppression database), and is suppressed on subsequent emails to any database within the same organization. Again, the suppression happens at send time when Acoustic Campaign is determining which contacts should receive a given email.