The BigFix Server and BigFix Relay's normal operations involve creating and processing a lot of temporary files. This activity is essential for good performance of BigFix, but can be slowed down dramatically or cause other anomalies if a virus scanner is scanning each file. To address this issue, configure your virus scanner on the BigFix Server, BigFix Relay and BigFix Console computers to exclude the BigFix Server folder and all subfolders (default is C:\program files\bigfix enterprise\bes server), the BigFix Relay and its subfolders (default is C:\program files\bigfix enterprise\bes relay), and the BigFix Console (these folders: C:\Program Files\BigFix Enterprise\BES Console\*, C:\Program Files (x86)\BigFix Enterprise\BES Console\*, C:\Users\*\AppData\Local\BigFix\*).
Refer to instructions from your virus scanner for more information on how to set this exclusion rule.
For more details, see the technote Should the BigFix agent be excluded from antivirus scanning?