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Pinned topic metadata database cannot be retrieved

‏2013-10-11T12:51:41Z |

i get the DWE7001E error when opening the infosphere warehouse console in browser.".....metadata database cannot be retrieved......". this is the error in the system.out log

RES37601E: The system cannot obtain an SQL connection for metadata database for the following reason [jcc][t4][2043][11550][3.63.138] Exception Error opening socket to server / on port 50,001 with message: Connection refused. ERRORCODE=-4499, SQLSTATE=08001


i checked the port, db2comm and tco/ip configurations are set correctly.  how am i to resolve this problem? there are control flows running every night and i find the database down every morning. please help.