The Mono http://www.go-mono.com/ folks at Ximian have, rather famously, brought .NET to Linux (and other Unixes). It remains, though, a "heavy" framework. It has a [b]lot[/b] going on, and starting with it can be intimidating.
Scripting fans can make themselves feel at home in the .NET world, though. Several open-source projects make .NET scriptable. Ticklesharp, for example, "can be used to add Tcl to any .NET application, giving you access to a full fledged scripting language. . . . TickleSharp is a portable binding to the Tcl/Tk scripting language for the .NET platform." That's what Scott Beasley says on the TickleSharp home page he's set up at http://forge.novell.com/modules/xfmod/project/?ticklesharp .