There is a new VSAM PTF UD54017 (APAR DY47526 ) available, that fixes the PTF UD53991 (APAR DY47507). PTF UD53991 is in error (PE).
The PTF UD54017 resolves a VSAM open error failing with return code X'22'. More details are in the APAR DY47526 description . The APAR will be flagged Hiper.
The failing PTF is also in the the latest z/VSE 5.1.2 Recommended Service Level (RSL) from January 31, 2014. That is please apply the new PTF UD54017 after you upgraded to that RSL.