You can create multiple data set separation profiles, but you can specify only one in an SMS base configuration (SCDS).
If you have created multiple SMS configurations, each configuration can share the same data set separation profile, or each can specify a different data set separation profile. Once an SMS configuration is activated, all systems within the SMS complex will share the same data set separation profile that is specified in the base configuration.
SMS reads the data set separation profile when SMS initializes with an active configuration, when SMS restarts, and when a configuration is activated or switched.